PNC-27 (5mg)

Description

Advance your oncology research, cellular apoptosis studies, and p53-MDM2 interaction investigations with high-purity PNC-27 (5mg).

PNC-27 is an advanced synthetic anti-cancer peptide consisting of a p53-derived residue combined with a p53-binding protein domain (specifically incorporating residues 12-26 of the p53 tumor suppressor protein linked to a cell-penetrating peptide). In biochemical literature, PNC-27 is celebrated for its unique mechanism of action: it selectively targets and binds to MDM2 proteins expressed within the plasma membrane of various neoplastic cells, inducing rapid pore formation and localized membrane lysis (tumor-specific necrosis/apoptosis) without harming non-malignant, healthy cells.

In laboratory and scientific settings, PNC-27 serves as an essential experimental tool to investigate targeted membrane-bound oncology pathways, selective cytotoxicity, and cancer cell apoptosis mechanisms. Researchers rely on this high-purity 5mg formulation to explore advanced anti-tumor assays, receptor-free membrane dynamics, and cellular death signaling in controlled in vitro and in vivo environments.

Key Research Benefits

• Targeted MDM2 Interaction: Selectively binds to membrane-anchored MDM2 proteins unique to malignant cell lines.

• Tumor-Specific Necrosis Studies: Serves as a benchmark compound for investigating selective pore formation and membrane lysis in cancer cell models.

• Apoptotic Pathway Assays: Facilitates precise experimental observation of targeted cellular death while sparing non-malignant, healthy cell populations.

• High-Purity Formulation: Engineered to stringent laboratory standards to guarantee structural stability, batch consistency, and reliable assay performance.

Usage & Handling Guide

• For Laboratory and Research Use Only: Strictly designated for scientific research, in vitro studies, and laboratory experimentation. Not intended for human consumption, clinical application, diagnostic procedures, or veterinary use.

• Reconstitution & Storage: Reconstitute using sterile bacteriostatic water or compatible laboratory buffers according to your experimental protocol. Store lyophilized powder at -20°C. Keep refrigerated between 2°C–8°C post-reconstitution.

Disclaimer: Purchaser assumes all responsibility for safe handling, appropriate laboratory protocols, and compliance with all local regulatory guidelines governing research chemicals.